Urea Metabolism in Chronic Renal Failure

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Urea metabolism in chronic renal failure.

Urea degradation was measured during 16 experiments in 13 chronic uremic patients being treated with essential amino acids or their analogues. [(14)C]Urea was injected i.v. and the clearance of labeled urea from its volume of distribution was compared with the simultaneous renal clearance of ordinary urea, which averaged 2.0 liters/day. The difference, extrarenal clearance of urea, averaged 3.1...

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1. Creatinine metabolism was studied in nine patients with severe chronic renal failure who were nevertheless in a nearly steady state with respect to their creatinine pool. Labelled creatinine was injected intravenously and the specific radioactivity of creatinine in urine was measured during the ensuing 5-7 days. 2. In each patient, the decline in specific radioactivity with time was a single...

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Abnormal Carbohydrate Metabolism in Chronic Renal Failure

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Urea distribution in renal failure.

An assessment of intracellular urea removed during haemodialysis has been made from urea extraction and plasma urea estimations. An apparent wide variation in the movement of intracellular urea in patients with acute renal failure from obstetric and traumatic causes and with chronic renal failure is reported.A method for the estimation of red cell water urea is presented. In two patients with c...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1974

ISSN: 0021-9738

DOI: 10.1172/jci107687